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NFL Football Pick - Detroit Lions (1-0) at San Francisco 49ers (1-0) Candlestick Park - San Francisco, California

Sunday, September 16th   8:20 p.m. (et)

NFL Football Pick
Detroit Lions (1-0) at San Francisco 49ers (1-0)
Candlestick Park - San Francisco, California

Two of last season best teams will clash in a Sunday Night Football battle at Candlestick Park.

The Niners are looking to pick up where they left off..The San Francisco 49ers started the 2012 season with an impressive win on the road against the Green Bay Packers. After going 13-3 in 2011, the Niners are looking to pick up where they left off and continue to be an elite team in the NFL.

In week two, San Francisco will host the Detroit Lions, who got by the Rams to start the season. The key to the game may be the Detroit defensive line against the 49er running game, which racked up 186 yards against Green Bay. Another key will be the play of 49ers quarterback Alex Smith. While Smith is not regarded as an elite QB, he was an effective game manager in 2011 and he will need to continue to make good decisions.

For San Francisco, it will be important to control talented wideout Calvin Johnson. Megatron is a challenge, even for a great defense like San Francisco, and he may be the key to offensive success for the Lions. Lions quarterback Matthew Stafford threw for 355 yards in week one, but he also threw three interceptions.

San Francisco has won the last eight meetings.

Detroit is 0-4-1 ATS in their last 5 road games.
Detroit is 0-3-1 ATS in their last 4 meetings versus San Francisco
Under is 6-0 in the last 6 meetings, 4-0 in the last 4 meetings in San Francisco.

Prediction: San Francisco 27, Detroit 16

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